急性冠脉综合征患者血清TNF-α、IL-6、IL-8变化的临床意义

The Clinical Significance of serum TNF - α, IL - 6, IL - 8 in Acute Coronary Syndrome patients

目的讨论肿瘤坏死因子（TNF—α）及白细胞介素（IL-6，IL-8）在急性冠脉综合征（ACS）患者血清中浓度变化及其意义。方法选取76例ACS患者，其中不稳定型心绞痛（UAP）患者37例，急性心肌梗死（AMI）39例；90例非ACS患者中稳定型心绞痛（SAP）患者49例，陈旧性心肌梗死（OMI）41例，冠脉造影正常者20例，采用放射免疫法测定上述病例的血清TNF—α．IL-6、IL-8浓度。结果（1）冠心痛组（SAP组、UAP组、AMI组、OMI组）血清TNF—α浓度均显著高于正常对照组；ACS组（UAP组、AMI组）血清TNF—α、IL-6、IL-8水平显著高于非ACS组（5AP、OIM组）；AMI组血清TNF—α水平显著高于UAP组；SAP组与OMI组血清TNF—α水平差异无显著性；而IL-6、IL-8差异显著。（2）SAP组与UAP组冠脉狭窄程度比较差异无显著性。结论TNF—α、IL-6、IL-8参与冠心病的形成；并且在ACS的发病中起重要作用。检测血清TNF—α浓度将有助于诊断和预测ACS的发生、发展和预后。

Objective Study the concentration changes of TNF - α, IL- 6, IL- 8 in serum and the changes＇cllnical significance in ACS. Methods 76 ACS patients were selected, there were 37 UAP patients and 39 AMI patients.90 non - ACS patients were selected, there were 49 SAP patients,41 OMI patients and 20 crowil arteries radiography normalcy patients. Estlmate the eoneentrgtion of TNF- α, IL- 6, IL- 8 in serum by madlolmmanoassay. Results （1）The concentration of TNF- α in serum in coronary heart disease patients（ SAP, UAP, OMI, AMI）is evident higher than that of control.The concentration2 of TNP - α,IL- 6,IL - 8 in serum in ACS is remarkable higher than those of non - ACS.The concentration of TNF - α in senan in AMI is higher than that of UAP,There are no statistics sisnifieanees of the changes of TNF - α concentration in serum between SAP and OMI, however the changes of IL - 6, IL - 8 eoneentmafion have statistics signifieanees in SAP and OMI. （2） The constriction degree of coronary has no statistics signifieanees in SAP and UAP. Conclusions TNF - α, IL - 6 and IL - 8 are related to CAD formation, and play an important role in CAD, the concentration of TNF - α, IL - 6 and IL - 8 in serum are help to the diagnosis and prediction of the occurrence, progress, prognosl in ACS.