临沂市127万新生儿疾病筛查回顾

The retrospect of 1.27 million neonatal disease screening cases in Linyi City

目的总结分析1999年9月-2009年12月间127万新生儿筛查疾病筛查经验。方法对辖区接产机构出生的新生儿采集外周血制成滤纸干血片，用酶联免疫吸附法（2007年至今使用时间分辨荧光免疫方法）作先天性甲状腺功能低下症（CH）的筛查，用细菌抑制法作笨丙酮尿症（PKU）筛查。结果共筛查新生儿1272136名，发现CH病例695例，发病率1／1830；发现PKU病例184例，发痛率1／6914。结论新生儿疾病筛查可以使患儿得到早期发现和诊治，降低了家庭和社会压力，对于减少残疾儿发生率、提高出生人口素质具有重要意义。

Objective To summarize and analyze the experience of 1.27 million neonatal disease screening cases from September 1999 to December 2009. Methods Collected peripheral blood from newborn babies in cow body area of Linyi City. and made them into dried blood filter papers, using enzyme - linked immunosorbent assay （2007 - present use of time - resolved fluoreseence immunoassay） for congenital hypothyroidism（CH） screening, with bacterial inhibition assay for phenylketonuria（PKU） screening. Results A total of 1272136 neonates screened and found 695 cases of CH patients, the incidence rate is 1/1830; found 184 cases of PKU patients, the incidence rate is 1 / 6914. Conclusion The babies with the disease can be found and cured earlier, so it will belp to reduce the pressure from the family and society, lower the occurrence rate of disability and improve quality of newborn babies.