超敏-C反应蛋白与急性脑血管病的相关性研究

The relativity study of High - sensitivity C - reactive protein and acute cerebralvascular disease

目的研究超敏-C反应蛋白（Hs—CRP）在急性脑血管病人中的变化，并探讨其与疾病的关系。方法收集275例住院的急性脑血管病患者，脑卒中患急性者245例，其中急性脑出血96例，急性脑梗死149例；短暂性脑缺血发作患者30例，同时选择年龄、性别比较相似的85名正常健康体检者，空腹抽血均以免疫速率散射测浊法测定其Hs—CRP的水平。结果急性脑血管病患者阳性率为75．64％：其中急性脑梗塞阳性率为75．17％，急性脑出血阳性率81．25％，短暂性脑缺血发作阳性率60．00％。脑卒中患者Hs—CRP的水平为（8．91±7．31）μg／L，与正常对照组[（1．09±0．12）mg／L]比较差异有显著性（P〈0．01）。脑梗死组和脑出血组血清Hs—CRP分别为（8．53±7．41）mg/L、（10．63±7．91）mg／L，脑出血组显著高于脑梗死组（P〈0．01）。大梗死患者的Hs—CRP比小梗死升高明显（P〈0．01），分别为（11．39±2．51）mg／L、（7．38±2．70）mg／L。部分病例10天后复捡Hs—CRP结果明显降低，有显著性差异（P〈0．01），与病情的康复相一致。结论Hs—CRP可能与急性脑血管病发病有关，急性脑血管病患者测定Hs—CRP浓度可以为临床评价病情的变化提供有意义的参考指标，Hs—CRP水平增高是急性脑血管病的独立危险因素。Hs—CRP与脑卒中的发生、发展密切相关，可以作为脑卒中转归的评价指标，临床在治疗时应充分考虑炎症反应这一危险因素。

Objeetive To study the diversification of Hs- CRP in acute cerebralvascular patient and to investigate the relation of the diversification and the acute cerebralvascular disease. Methods Collected 275 cases of hospitalized patients with acute cerebravascular disease, 245 cases of acute stroke patients, In which 96 patients with acute cerebral hemorrhage patient, 149 cases of acute cerebral infarction patient; 30 cases of transient isehemic attacks, At the same time choose the age, sex, compared to 85 similar cases of normal healthy individuals and measure those levels of Hs - CRP at fasting blood in Immunization rates measured scatterhng turbidimetry. Result The positive rate of Hs - CRP is 75.64 % in acute cerebralvascular patients ：.among them 75.17 % in acute cerebral infarction patient, 81.25 % in acute cerebral hemorrhage patient,60.00% in transient isehemic attacks.There was a significant difference between the level of Hs- CRP （8.91 ± 7.31 ）mg/L in acute stroke patients and that in normal control group （1.09 ± 0.12） mg/L. The serum levels of Hs- CRP Cerebral infarction and cerebral hemorrhage, respectively, （8.53 ±7.41 ） mg/L,（ 10.63 ± 7.91 ）mg/L, Cerebral hemorrhage group was significantly higher than the CI group（p 〈 0.01） .The level of Hs- CRP of large area of cerebral infarct size increased significantly than the small area of cerebral infarct（p 〈 0.01 ）,are （11.39 ± 2.51） mg/L,（7.38 - 2.70） mg/L. Some eases the re - examination level of Hs - CRP is significantly lower 10 days after, there are significant differences, Is consistent with the rehabilitation of the disease （p 〈 0.01 ）. Conclusion Hs- CRP may be related to the pathogenesis of acute cerebravascular disease, Determination of acute cerebravaseular disease in patients with Hs - CRP concentration can provide a meaningful reference for changes in chnical evaluation of the disease, Hs - CRP increased levels is an independent risk factor of acute cerebravascular disease. Hs - CRP is closely related to the occurrence and development of stroke, and can be used as evaluation index of prognosis of stroke, inflammatory response, this risk factor, should be fully considered in the treatment of clinical.