米非司酮配伍米索前列醇抗早孕300例临床观察

Clinical observation of 300 cases of anti-early pregnancy with mifepristone and misoprostol

目的探讨米非司酮配伍米索前列醇抗早孕的临床疗效。方法选择2005年6月～2009年6月该站收治的要求药物流产的早孕女性300例,随机将患者分为观察组和对照组,每组150例。观察组患者采用口服米非司酮与米索前列醇配伍治疗,对照组患者则采用负压吸引人流术终止妊娠。对两组患者的临床疗效、出血情况及不良反应等指标进行对比分析。结果与对照组相比,观察组完全流产的比率明显提高,差别具有统计学意义(P<0.05),而不全流产及失败的比率均有不同程度降低,差别不具有统计学意义(P>0.05)。与此同时,与对照组相比,观察组多于经量一倍及出血时间大于2周的比率明显降低,差别亦均具有统计学意义(P<0.05)。结论在米非司酮与米索前列醇配伍治疗早孕女性的过程中,其流产成功率高、出血量少、出血时间短、毒副作用小,是一种安全有效、简单方便的药物流产方法。

[Objective] To investigate clinical effecfiveness of 300 cases of anti-early pregnancy with mffepristone and misoprostol. [Methods] From June 2005 to June 2009 admitted 300 cases of early pregnancy who requested hospital medical abortion were randomly divided into two groups, and 150 cases as control group. The observation group was treated with oral mifepristone and misoprostol in combination with therapy, control patients received vacuum attraction bypass termination of pregnancy. Two groups of patients with the clinical efficacy, bleeding and adverse reactions such indicators were analyzed. [ Results ] Compared with control group, complete abortion rate of the observation group significantly improved, there were significant differences （P 〈0.05）. Instead of the whole abortion and failure rate of decrease in varying degrees, there was no significant difference （P 〉0.05）. At the same time, compared with control group, the menstrual flow of observation group was doubled and the amount of bleeding time by more than 2 weeks significantly reduced , there were also significant differences （P 〈0.05）. [ Conclusions] In early pregnancy with mifepristone and misoprostol is a safe and effective, simple and convenient method of medical abortion.