耐多药结核病家庭传播的分析与防护

Investigation of transmission and protection in family of pulmonary MDR-TB

目的分析家庭密切接触者患耐多药结核病（MDR-TB）的情况，探讨指导家庭防护的必要性及迫切性。方法对我院9例临床典型的、既往有肺结核家庭背景的密切接触史的原发MDR-TB患者所密切接触的亲属情况以及他们自身的治疗转归进行回顾性分析。结果9例患者均为直系亲属患肺结核而被感染为MDR—TB，其中1例全家3代均患有肺结核，1例全家4口均患肺结核。9例患者中肺叶切除2例，肠结核切除1例；治愈3例，未治愈2例，死亡4例。结论对传染性肺结核家庭密切接触者，应早期干预，体现在宣教、有效防护和定期健康体检等多方面。

Objective To investigate the situations of close contacting with MDR-TB in family and analysis the necessity and urgency of family protection. Methods Nine typical primary MDR-TB cases in our hospital that close contacted with family pulmonary TB patients, their relatives contacted with them and their treatment prognosis were retrospectively analyzed. Results All of the 9 cases were transmitted by lineal MDR- TB relatives. In one case,3 generations were pumonary TB patients. All of 4 family members were pulmonary TB patients in another case. 3 cases were treated with operations ： 2 cases with pulmonary lobectomy and 1 case with intestinal resection. Treatment prognosis： 3 cases cured, 2 cases not cured, 4 cases dead. Conclusions Family close contacting with MDR-TB patients should be intervened earlier： including health education, effective protection and health examination regularly et al.