环氧合酶-2与急性胰腺炎研究进展

Advances in understanding the role of cyclooxygenase-2 in the pathogenesis of acute pancreatitis

胰腺大量消化酶的激活并释放和胰腺微循环紊乱是急性胰腺炎的始动因素之一.许多刺激因子诱导的炎症反应均有环氧合酶-2(cyclooxygenase-2,COX-2)的表达.COX-2可以促进早期炎症的发展和诱发胰腺的微循环障碍.

Activation and release of digestive enzymes and pancreatic microcirculatory disturbance are initiators of acute pancreatitis.The expression of cyclooxygenase-2 （COX-2） has been detected in inflammatory response induced by many stimulating factors.COX-2 can promote the development of early inflammation and induce pancreatic microcirculatory disturbance.