缺血后处理对肝脏缺血再灌注的保护机制研究进展

Advances in research on the protective mechanisms of ischemic postconditioning against hepatic ischemia-reperfusion injury

肝脏移植是治疗终末期肝病的唯一有效手段,缺血再灌注损伤是移植肝功能受损乃至丧失的主要因素之一.缺血后处理是在组织器官长时间缺血后再灌注早期,对组织器官进行数次短暂的再灌注/阻断的处理方法.众多研究显示,缺血后处理对肝脏缺血再灌注损伤有保护作用.他发挥作用的可能机制,主要是通过对氧自由基、钙超载、中性粒细胞、细胞因子、细胞凋亡、线粒体等几个方面的作用来实现.

Liver transplantation is the only effective treatment for end-stage liver diseases.Ischemiareperfusion injury remains a major cause of post-transplantation liver dysfunction and even failure.Ischemic postconditioning is defined as rapid intermittent periods of reperfusion and ischemia in the early phase of repefusion after long ischemia of the tissues and organs.Many investigations have demonstrated that ischemic postconditioning has a protective effect against hepatic ichemia-reperfusion injury.Ischemic postconditioning exerts protective effects through many possible mechanisms such as oxygen free radicals,calcium overload,polymorphonuclear neutrophils,cytokines,cell apoptosis and mitochondria.