妊娠期糖尿病妇女血清瘦素、体脂含量和胰岛素抵抗的相关性

Relationship among serum leptin concentration,body fat percentage and insulin resistance in pregnant women with gestational diabetes mellitus

目的探讨妊娠期糖尿病(GDM)妇女血清瘦素水平、体脂含量(BFP)和胰岛素抵抗(IR)三者之间的相关性。方法 GDM妇女和正常孕妇各100例,于妊娠26～30周分别检测血清瘦素水平;测空腹胰岛素水平和空腹血糖水平,计算IR;同时测皮下皱褶厚度,计算BFP。结果与正常孕妇比较,GDM妇女血清瘦素水平较高、IR增加、BFP增加。多元Logistic回归分析显示,在GDM妇女中,若排除了其他影响因素,瘦素浓度随着体脂含量的增加而增加(P<0.01),且瘦素浓度亦随着IR的增加而增加。结论瘦素在GDM的发病中具有潜在作用,GDM妇女体内存在瘦素抵抗和胰岛素抵抗,两者相互影响。

Objective To study the relationship among serum leptin concentration,body fat percentage（BFP） and insulin resistance（IR） in pregnant women with gestational diabetes mellitus（GDM）.Methods Venous blood samples were taken in 100 pregnant women with GDM and 100 normal pregnant women between 26 and 30 gestational weeks for the measurements of serum insulin and leptin.IR was calculated.BFP was calculated from skinfold thickness measurements as well.Results Compared to the normal pregnant women,BFP,IR and leptin concentration were significantly higher in pregnant women with GDM.Multivariate analysis showed that,excluding the other factors,the leptin levels increased as BFP and IR increased（P0.01）.Conclusion Leptin has a potencial role in the development of GDM.There are leptin resistance and insulin resistance in GDM,which effect each other.