布地奈德混悬液加沐舒坦雾化吸入对鼻咽癌放疗性耳鼻并发症的疗效

Efficacy of aerosol inhalation of budesonide suspension plus mucosolvan in radiotherapy-induced complications of ear and nose in patients with nasopharyngeal carcinoma

目的观察布地奈德混悬液加沐舒坦(BSM)氧气驱动雾化吸入治疗对鼻咽癌放疗所致耳鼻并发症的影响。方法 54例鼻咽癌分为两组,每组27例。干预组在放疗期间以BSM氧气驱动雾化吸入治疗;对照组在放疗期间无上述治疗。待放疗结束时比较两组语言频区气导听阈、分泌性中耳炎发生率、副鼻窦炎发生率、鼻腔粘连和后鼻孔狭窄发生率。结果干预组语言频区气导听阈和分泌性中耳炎、副鼻窦炎、鼻腔粘连和后鼻孔狭窄发生率均低于对照组(P<0.05)。结论鼻咽癌放疗期间给予BSM氧气驱动雾化吸入治疗可降低放疗所致耳鼻并发症。

Objective To investigate the effects of aerosol inhalation using budesonide suspension plus mucosolvan（BSM） on radiotherapy-induced complications of ear and nose in nasopharyngeal carcinoma（NPC）.Methods Fifty-four cases were divided into two groups with 27 cases each.The patients in group A were treated with BSM during radiotherapy and those in group B without as the controls.At the end of radiotherapy,the radiotherapy-induced complications were compared between two groups.Results The incidence rates of average hearing in language frequency,otitis media with effusion nasopharyneal,nasal adhesion and postnasal stenosis were all lower in group A than those in group B（P0.05）.Conclusion Aerosol inhalation with BSM during radiotherapy can effectively decrease radiotherapy-induced complications of the ear and nose in patients with NPC.