卡米可林在青光眼联合白内障术中的临床应用观察

Clinical observation of carbamycholine in glaucoma and cataract surgery

目的:观察卡米可林在青光眼小梁切除联合白内障超声乳化人工晶状体植入术中的临床应用。方法:我院2007-01/2008-01收治的慢性闭角型青光眼合并年龄相关性白内障患者97例120眼,随机分为3组:A组白内障超声乳化术后结膜囊点卡米可林组(观察组),B组白内障超声乳化术后前房应用卡米可林置换组(置换组),C组白内障超声乳化术后前房应用卡米可林留置组(留置组);观察各组术后眼压、视力、前房渗出、虹膜周切口及并发症等(各组40眼,年龄60～80岁,随访12mo)。结果:术后A,B组早期眼压控制显著优于C组,差异有显著意义(P<0.05),但晚期眼压控制3组间差异无显著意义;术后A,B组早期视力改善显著优于C组,差异有显著意义(P<0.05),晚期无明显差异;虹膜周切口大小适中率3组间差异无显著意义,术后前房渗出A组明显低于B,C组,3组间差异有显著意义(P<0.05)。结论:青光眼联合白内障术中应用卡米可林可加重术后反应,但合理应用后可明显减少其副作用。

· AIM：To observe the clinical application of carbamycholine in the trabeculectomy combined with cataract phacoemulsification and intraocular lens implantation.· METHODS：Ninety-seven patients 120 eyes with chronic angle-closure glaucoma with age-related cataract from January 2007 to January 2008 were randomly divided into three groups：the observation group（group A,conjunctival sac carbamycholine dropping after phacoemulsification）,the replacement group（group B,the anterior chamber carbamycholine replacement after phacoemulsification）and the retention group（group C,the anterior chamber carbamycholine detain after phacoemulsification）.Intraocular pressure（IOP）vision,anterior chamber exudation,iris weeks incision and complications in each group（40 eyes,aged 60-80 years old,followed-up for 12 months）were observed.· RESULTS：Early IOP control of A,B group was significantly better than that of C group;and the difference was statistically significant（P〈0.05）,but later IOP control among the three groups showed no significant difference;early visual acuity of A,B group was significantly better than that of C group,the difference was statistically significant（P〈0.05）,but later visual acuity showed no significant difference;the moderate rate of iris incision size among the three groups showed no significant difference;the anterior chamber exudation of group A was lower than that of B,C group,the difference among the three groups was significant（P〈0.05）.· CONCLUSION：Carbamycholine application in glaucoma with cataract surgery can increase postoperative response,while reasonable application can significantly reduce its side effects.·