Toll样受体2在类固醇性痤疮中的表达

Enhanced Expression of TLR2 in Steroid Acne

目的研究Toll样受体2(TLR2)在类固醇痤疮发病过程中的作用。方法收集62例类固醇激素性痤疮患者皮肤组织,免疫组织化学法检测TLR2的表达水平;体外培养皮肤角质形成细胞系Hacat细胞,实时定量PCR及Western blot法检测地塞米松对TLR2表达的影响。结果类固醇痤疮患者的痤疮样皮损TLR2的表达较正常组明显增高。地塞米松能显著上调静止Hacat细胞TLR2的表达;也能进一步增强痤疮丙酸杆菌刺激的Hacat细胞中TLR2的表达。结论皮质类固醇激素对TLR2表达的增强作用可能参与了类固醇激素性痤疮的发生发展。

Objective To investigate the role of TLR2 in the steroid acne.Methods Toll-like receptor-2 （TLR2） expression in steroid acne was determined by immunohistochemistry.TLR2 expression in cultured Hacat cells,in the presence of dexamethasone and Propionibacterium acnes （P.acnes）,was also measured.Results An increased in the expression of TLR2 was found during eruption of steroid acne.The expression of TLR2 was also enhanced in Hacat cells treated with dexamethasone and P.acnes.Conclusion Steroid-induced TLR2 expression may influence the development of steroid acne.