慢性乙型肝炎患者外周血T淋巴细胞亚群的观察

Characteristics of peripheral T-lymphocyte subsets in chronic hepatitis B patients

目的:观察慢性乙型肝炎患者外周血T淋巴细胞亚群的改变。方法:观察比较慢性乙型肝炎患者及正常健康人的外周血T淋巴细胞亚群差异;并比较慢性乙型肝炎转氨酶正常者与异常者外周血T淋巴细胞亚群差异。结果:慢性乙型肝炎患者CD4+、CD8+T细胞计数及CD4+/CD8+低于正常人;慢性乙型肝炎血清转氨酶异常者与转氨酶正常者比较,CD3+、CD8+T细胞计数升高,CD4+/CD8+比值降低。结论:慢性乙型肝炎患者存在细胞免疫功能的低下。

Objective：To observe characteristics of peripheral T-lymphocyte subsets in chronic hepatitis B patients.Methods：Differences of the number of T-lymphocyte subsets in chronic hepatitis B patients and control group were observed;Differences of the number of T-lymphocyte subsets in abnormal alanine transaminase and normal alanine transaminase group were observed.Results： The number of CD4^＋,and CD8^＋ T-lymphocyte subsets in peripheral blood as well as CD4^＋/CD8^＋ ratio in chronic hepatitis B patients were significantly lower than those in control group;The number of CD3^＋,and CD8^＋ T-lymphocyte subsets in peripheral blood were significantly higher and CD4^＋/CD8^＋ ratio was significantly lower in chronic hepatitis B patients than those in control group.Conclusions： Decreased cellular immune function and immune dysregulation are noted in chronic hepatitis B patients.