文拉法辛缓释片与氟西汀治疗抑郁症临床对照研究

Controlled study of Venlafaxine-xr tablets and Fluoxetine in treatment of depression

目的:探讨文拉法辛缓释片治疗抑郁症患者的疗效及安全性。方法:将60例抑郁症患者随机分为文拉法辛组(研究组,30例)和氟西汀组(对照组,30例),进行开放式临床对照研究,疗程均为8周。采用汉密尔顿抑郁量表(17项,HAMD)及躁狂抑郁印象量表(CG I-BP)评价疗效,采用药物不良反应量表(TESS)评价不良反应。结果:治疗8周后,文拉法辛组和氟西汀组的HAMD总分均明显减低,文拉法辛组HAMD减分率为(61.0±14.0)%,氟西汀组为(60.0±12.5)%,差异无统计学意义(t=0.063,P=0.951)。文拉法辛组临床总有效率为86.6%,氟西汀组为83.3%,差异无统计学意义(x2=0.131,P=0.718)。文拉法辛组的不良反应发生率为23.3%(7/30),氟西汀组为26.6%(8/30),差异无统计学意义(x2=0.089,P=0.766)。结论:文拉法辛缓释剂治疗抑郁症患者起效较快,疗效确切,安全性好。

Objective：To evaluate the efficacy and safety of venlafaxine＇ xr in treatment of depression.Methods：60 cases with depression were divided randomly into two groups： Venlafaxine（30 cases） and fluoxetine（30 cases）.All patients were treated and observed within 8 weeks.The efficacy was evaluated by the HAMD and CGI-BP and the side effects were assessed by the TESS.Results： The score of venlafaxine and fluoxetine group are significantly declined within 8 weeks.The HAMD of Venlafaxine group has a（61.0±14.0） % reduction of 86.6% total efficiency;The HAMD of Fluoxetine group has a（60.0±12.5） % reduction of 83.3% total efficiency.There are no significant statistical difference（P〉0.05） between these two groups.The rate of side effects of Venlafaxine is 23.3%,and the Fluoxetine group is 26.6%.There are no significant statistical difference（P〉0.05） between them.Conclusions： Venlafaxine＇ xr is rapid,effective and safe in treatment of depression.