绝经后2型糖尿病患者雌二醇受体的变化

The Change of Estradiol Receptor Level in Postmenopausal NIDDM Patients

目的：探讨雌二醇受体（ＥＲ）数目与绝经后２型糖尿病的关系。方法：随机选测绝经后２型糖尿病患者３０例和６０例正常妇女（绝经前后各３０例）。采用放射配体法检测外周血白细胞ＥＲ含量；采用放射免疫法检测血浆雌二醇（Ｅ２）浓度。结果：绝经后２型糖尿病组白细胞ＥＲ及血浆Ｅ２不仅非常显著低于正常绝经前组（Ｐ＜０．００１），且较正常绝经后组也明显下降（Ｐ＜０．０１）。结论：绝经后２型糖尿病的发病可能与雌二醇及ＥＲ的降低有关。

Objective:To explore the changes of estradiol receptor (ER) numbers and its relation with postmenopausal non insulin dependant diabetes mellitus(NIDDM).Methods:ER on blood white cells were measured by radioligand binding assay in women divided to 3 groups:group A postmenopousal with NIDDM (n=30); group B normal postmenopausal(n=30);group C normal premenopausal (n=30). Plasma estradiol(E2) conceutration with radioimmuoassay were also measured.Results:The levels of E2 and ER in group A were all lower remarkly than those of group C(P<0.001) and group B(P<0.01). Conclusion:The pathogenesis of postmenopausal NIDDM may be related with the reductions of E2 and ER.