摘要
目的：设计合成有抗菌抗肿瘤活性的喹诺酮药物。方法和结果：根据推理药物设计原理，设计并合成了１６个新型抗菌抗肿瘤喹诺酮类化合物，并研究其构效关系。结论：用９株细菌及４株肿瘤细胞评价了它们的体外抗菌活性（ＭＩＣ值）及抗肿瘤活性（抑瘤率％）。其中。
AIM: To design and prepare quinolone compounds with antibacterial and antitumor activities. METHODS AND RESULTS: According to rational drug design principle, a series of novel analogues of (S) (-) ofloxacin has been prepared and the influences on structure activity relationships was also discussed. CONCLUSION: Their in vitro antitumor and antibacterial activities were evaluated. The results showed that compound 16～20 have good antitumor and antibacterial activities.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第2期119-124,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
上海市科技启明星计划资助项目
关键词
左旋氧氟沙星
合成
抗肿瘤活性
抗菌活性
antitumor quinolone
(S) (-) ofloxacin
synthesis
antitumor activity
antibacterial activity
