苦葛蔓中的新三萜成分

NEW TRITERPENOIDS FROM PUERARIA PEDUNCULARIS

目的：对苦葛蔓（ＰｕｅｒａｒｉａｐｅｄｕｎｃｕｌａｒｉｓＧｒａｈ．）酸水解产物中的化学成分进行分离和结构鉴定。方法：用各种色谱技术进行分离，得到３个五环三萜化合物，用ＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ（ＤＥＰＴ），ＨＭＱＣ，ＨＭＢＣ和ＮＯＥＳＹ谱鉴定化合物。结果：经光谱鉴定化合物１为３β，１５α，２３三羟基齐墩果１２烯１６酮，化合物２为３β，１５α二羟基齐墩果１２烯１６酮，化合物３为３β，２２β，２４三羟基齐墩果１２烯（ｓｏｙａｓａｐｏｇｅｎｏｌＢ）。结论：化合物１和化合物２为新化合物。

AIM: To investigate the chemical constituents of the herbs of Pueraria peduncularis Grah. METHODS: Column chromatography were used to separate the chemical constituents. MS, IR, 1HNMR , 13 CNMR (DEPT), HMQC, HMBC and NOESY were used to determine the structures of the isolated constituents. RESULTS: Three pentacyclic triterpenoids were elucidated as 3β,15α,23 trihydroxy olean 12 en 16 one (1), 3β,15α dihydroxy olean 12 en 16 one (2) and 3β,22 β,24 trihydroxy olean 12 ene (soyasapogenol B, 3) on the basis of spectral evidence. CONCLUSION: Compounds 1 and 2 are new compounds.