住院肺结核病人对氧氟沙星耐药的分析

Analysis of ofloxacin(OFLX)resistance of in patients with pulmonary tuberculosis

目的探讨住院肺结核病人对氧氟沙星的耐药性。方法就１９９３年１月～１９９５年１２月我院住院肺结核病人痰结核菌培养阳性并有药敏结果者２０５例进行了对氧氟沙星耐药性的回顾性调查。结果继发耐药者１１例（１７５％），原发耐药者２例（１４％），通过对氧氟沙星耐药病例的分析，考虑用药时间长及相当于单一用药是氧氟沙星继发耐药产生的原因；而原发耐药的产生，可能与感染耐药菌有关。此外，对氧氟沙星耐药者的疗效明显不及敏感者。结论目前氧氟沙星耐药率较低，故氧氟沙星不失为临床上一个新的、有效的抗结核药。

Objective To study the resistance of OFLX of in patients of pulmonary tuberculosis.Methods Retrospective investigation of 205 cases with pulmonary tuberculosis from Jan.1993 to Dec.1995 in our hospital.All cases were sputum culture positive and possessed drug susceptibility test rusults.Results The result showed that 11 cases(17 5%)occurred secondary resistance,2 cases(1 4%) occurred primary resistance.The analysis of patients with OFLX resistant bacilli suggests that long time administration of anti TB drugs and equivalent to monotherapy with OFLX are the causes of secondary resistance and infected by OFLX resistant bacilli may be associated with primary resistance.In addition,the therapeutic effects of OFLX sensitive cases are remarkably superior to OFLX resistant cases.Conclusion OFLX is a new and effective anti tuberculosis drug for it's effect and low rate.