卡介苗接种对体液免疫的影响及其临床意义

Influence of BCG vaccination on humoral immunity of human beings and its clinical significance

目的观察卡介苗接种（简称种卡）与体内抗结核抗体变化间的关系。方法测定５３例新兵种卡前及种卡后第１２周和第２４周时血清中抗ＰＰＤ抗体（ＰＰＤＩｇＧ）的ＯＤ值并与种卡前进行对比分析。结果５３例新兵种卡前ＰＰＤＩｇＧ２例（３８％）阳性，种卡１２周后１５例（２８３％）阳性，种卡２４周后９例（１７０％）阳性，抗ＰＰＤ抗体ＯＤ值种卡后第１２周较种卡前明显升高（Ｐ＜０００１）。结论接种卡介苗后ＰＰＤＩｇＧ水平升高说明种卡可以提高机体对结核菌的体液免疫水平，且可在较长时间内维持。

Objectives To observe the influence of BCG vaccination on the humoral immunity to tuberculosis bacilli.Methods The serum antibodies to PPD(PPD IgG) of 53 recruits were measured before and after BCG vaccination(12 and 24 weeks later).The OD value of them was compared between 3 measurements.Results Before BCG vaccination,there were 2 cases(3.8%) with positive PPD IgG,At the 12th week after BCG vaccination,there were 15(28.3%)positive;Followed by next 12 weeks,there were 9(17.0%)positive.The OD value of PPD IgG was higher significantly after BCG vaccination,compared with that before( P <0 001).Conclusions The increasing of PPD IgG after BCG vaccination shows that it can boost human beings humoral immunity to tuberculosis bacilli and keep that at a high level.This may interfere with the serological diagnosis of active tuberculosis among children.