猪无肝期静脉-静脉被动转流的血流动力学变化

Changes of Hemodynamics during Anhepatic Phase with Passive Veno Venous Bypass in Pigs

目的与方法：对８只平均体重２５±１２９ｋｇ的幼猪原位肝移植时行无肝期静脉静脉被动转流，观察其对血流动力学的影响。结果：与无肝前期比较，无肝期的肺小动脉嵌压（ＰＡＷＰ）、体循环血管阻力指数（ＳＶＲＩ）和下腔静脉压（ＩＶＰ）明显升高，心脏指数（ＣＩ）、每搏指数（ＳＶＩ）、左室每搏功指数（ＬＶＳＷＩ）和右室每搏功指数（ＲＶＳＷＩ）下降极显著，平均动脉压（ＭＡＰ）有一定程度下降，而中心静脉压（ＣＶＰ）、肺动脉压（ＰＡ）只有轻微变化。结论：静脉静脉被动转流在无肝期对减轻门脉系统瘀血，改善肠管血液循环，防止肠道菌群移位等方面有一定作用。

Objective and Methods: To observe the hemodynamic efficts of passive veno venous bypass during the anhepatic phase of orthotopic liver transplantation in 8 pigs weighted 25±1 29kg. Results: Compared with preanhepatic phase, PAWP, SVRI and IVP significantly rose. CI, SVI, LVSWI, and RVSWI were markedly depressed. MAP fell to a certain extent. While changes of CVP and PA were mild. Conclusion: Passive veno venous bypass during the anhepatic phase has some benificial effect on alleviating extravasated blood in janitrix system, improving circulation and preventing flora shift in the intestinal tract.