保定市区中老年人糖代谢异常及其危险因素的研究

Abnormal glucose regulation and the risk factors in middle-aged and elderly residents from Baoding City

目的了解保定市区中老年人2型糖尿病(T2DM)和糖尿病前期(IGR)的患病情况,并分析其糖代谢异常的危险因素。方法采用随机整群抽样方法,从保定市所有社区中随机抽取3个社区,对社区内所有40岁以上的常住居民(3212人)进行问卷调查、体检和实验室检查,其中问卷调查包括一般情况、既往病史、生活方式及精神状况、膳食情况等;体格检查包括身高、体重、腰围、臀围和血压;实验室检测包括空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和餐后2小时血糖。采用多因素累积Logistic回归法分析其糖代谢异常的影响因素。结果 T2DM、单纯空腹血糖受损(1-IFG)、单纯糖耐量受损(1-IGT)和空腹血糖受损合并糖耐量受损(IFG/IGT)的标化患病率分别为19.03%、1.42%、5.92%和1.34%,27.72%的人受到糖代谢异常的威胁。多因素累积Logistic回归显示性别、年龄、职业、水果摄入量、脾气性格、体质指数(BMI)、腰围(WC)、腰臀比(WHR)、收缩压(SBP)、甘油三酯(TG)、糖尿病家族史及女性有巨大儿生育史与中老年人患糖代谢异常有关,其中女性和经常摄入水果为保护因素。结论保定市区中老年人群中T2DM的患病率较高,其发病受多种因素的影响。

Objective To assess the prevalence of type 2 diabetes mellitus （ T2DM） and impared glucose regulation（IGR） in the residents of Baoding City,including 1-impaired fasting glucose（1-IFG）,1-impaired glucose tolerance（1-IGT） and IFG /IGT,to identify the main risk factors of abnormal glucose regulation.Methods A sample of 3212 community residents aged over 40 years old was selected from three communities of Baoding City by random cluster sampling.The survey was conducted by trained investigators using a standardized questionnaire.The subjects received physical examination and laboratory test,such as SBP,SDP,TC,TG,LDL-C,HDL-C,FBG,2h PG,WHR and BMI.The data were analyzed by Accumulative Logistic Regression.Results The standardized prevalence of T2DM,1-IFG,1-IGT and IFG /IGT was 19.03% ,1.42% ,5.92% and 1.34% ,and 27.72% of residents over 40 yeas old in Baoding City threatened by the trouble of abnormal glucose regulation.The results demonstrated that the gender,age,occupation,fruit intake,temper or disposition,BMI,WC,WHR,SBP,TG, DM family history and the history of fetal macrosomia （female only） were significantly associated with the abnormal glucose regulation,but taking more fruits and the female sex were protective factors.Cardio-cerebrovascular disease was the highest among the complications prevalent in diabetic patients,more than one complication is common,and the detection rate of new diabetic patients was 8.19% .Conclusion The prevalence of T2DM is high in the residents of Baoding City,which is influenced by many factors.