围生期妇女骨量和骨代谢及其影响因素研究

Investigation on bone mass,bone metabolism and effect factors in women during perinatal period

目的:探讨围生期妇女骨量和骨代谢及其影响因素。方法:选取2008～2009年100例孕产妇为研究对象,将其设为观察组,选取同期的100例未孕妇女为对照组,将观察组孕早期、孕中期及孕后期和对照组的血清磷、钙、骨碱性磷酸酶、骨钙素、尿钙/肌酐及抗酒石酸酸性磷酸酶、雌二醇等进行检测及比较。结果:经研究比较发现,随着孕周的增加,观察组孕后期血清磷、钙、骨钙素降低,而则尿钙/肌酐、骨碱性磷酸酶、抗酒石酸酸性磷酸酶、雌二醇升高,孕后期与孕中期、孕前期及对照组比较,P<0.05或P<0.01,有统计学差异。结论:对于围生期妇女进行监测骨量和骨代谢较为重要,以便及时采取补钙措施。

Objective：To explore the bone mass,bone metabolism and effect factors in women during perinatal period.Methods：100 pregnant women were selected as observation group from 2008 to 2009,100 non-pregnant women synchronization were selected as control group,The serum levels of phosphorus,calcium,bone alkaline phosphatase,osteocalcin,urinary calcium/creatinine,tartrate-resistant acid phosphatase and estradiol in observation group of early,second trimester and late pregnancy and control group were detected and compared.Results：With the increase of gestational age,the serum levels of phosphorus,calcium and osteocalcin in observation group of late pregnancy decreased,while the serum levels of urinary calcium/creatinine,bone alkaline phosphatase,tartrate-resistant acid phosphatase and estradiol increased,there was significant difference among observation group of early,second trimester and late pregnancy and control group （P〈0.05 or P〈0.01）.Conclusion：For women during perinatal period,the monitoring of bone mass and bone metabolism is important,in order to take measures to supply calcium.