巯甲丙脯酸治疗老年充血性心力衰竭200例疗效观察

The oberservation of captopril effect in treating senile heart failure in 200 cases

目的对巯甲丙脯酸治疗老年充血性心衰进行疗效评价，探讨其临床使用价值。方法观察病人治疗前后１周血压（ＢＰ）、心脏收缩功能、舒张功能、心功能不全的改善、预后，并与对照组比较。结果用巯甲丙脯酸治疗组与对照组相比较ＢＰ、ＥＦ、ＳＶ、ＰＡＶ、ＰＥＶ、Ａ／Ｅ及心功能、预后有明显改善（Ｐ＜０．０５）。结论巯甲丙脯酸可抑制心衰时激活的肾素—血管紧张素—醛固酮系统（ＲＡＳ），阻止充血性心力衰竭的发展，改善充血性心力衰竭的预后。

Objectives To evaluate the captopril in treating senile heart failure and research in clinical practicle value.Methods To opsevate the BP of patient pre and post treatment,heart antractle and dicatation function and the compansiv of the improment of insufficient heart function,prograsis and compare with those of controlled group.Results Captopril group in compansiv of the controlled group:BP、EF、SV、PAV、PEV、A/E and heant function,all showed significant improment ( P <0.05).Conclusions During heart failure,the renin-angiotension aldosteron (RAS) would be activted,but the captopril could inhibite these activation,hindered the deterioration of heart failure,thus the progrosis of heart failure might be considerally ameliorated