施他宁对门脉高压性胃病治疗的实验研究

Study on stilamin in the treatment of portal hypertensive gastropathy in rats

目的：探讨施他宁对门脉高压性胃病（ＰＨＧ）的治疗作用。方法：部分结扎大鼠门脉主干２周制作ＰＨＧ模型，观察施他宁对ＰＨＧ大鼠全身血流动力学、胃粘膜血流量（ＧＭＢＦ）、门脉压力（ＰＶＰ）和胃粘膜下层血管的影响，测定了输注施他宁３０ｍｉｎ后ＰＨＧ大鼠血浆胰高糖素，血浆和胃粘膜６－ｋｅｔｏ－ＰＧＦ１α含量，并与普萘洛尔进行了对比。结果：施他宁和普萘洛尔均能降低ＰＶＰ、ＧＭＢＦ，而对胃粘膜下层血管无影响；施他宁能拮抗ＰＨＧ大鼠胰高糖素作用、抑制胃酸和胃蛋白酶，对平均动脉压（ＭＡＰ）和心率无明显影响，普萘洛尔与施他宁相反；普萘洛尔和施他宁两组均不能拮抗ＰＧＩ２。结论：施他宁通过拮抗ＰＨＧ大鼠胰高糖素的作用降低ＧＭＢＦ。

Objective: To observe the effects of stilamin on portal hypertensive gastropathy (PHG) in rats. Methods: Two weeks after portal vein ligation, the changes of hemodynamics, GMBF, PVP , and submucosal blood vessels were observed;plasma glucagon, plasma and gastric mucosal 6 keto PGF 1α were tested after intravenous stilamin, propranolol and saline. Results: GMBF and PVP were reduced whereas submucosal blood vessels were not changed after intravenous stilamin and propranolol.Stilamin decreased plasma glucagon,hindered gastric acid and pepsin secretion, had no effect on MAP and heart rate of PHG rats as compared with control group of PHG, whereas propranolol had no such effects, but it might decrease MAP and heart rate. There were no differences in plasma and gastric mucosal 6 keto PGF 1α levels between all PHG groups. Conclusion: Stilamin reduced GMBF of rats with PHG by hindering glucagon, and had no effect on hemodynamics.