唐山地区乳腺癌患者血清有机氯农药残留物水平研究

Study on the levels of serum organochlorine pesticides residues in breast cancer patients from Tangshan areas

目的 研究唐山地区乳腺癌和乳腺良性疾病患者血清有机氯农药残留物水平.方法 收集唐山地区（丰南区和唐海县）乳腺疾病患者287例,乳腺癌组158例,乳腺良性疾病组129例.采用附ECD检测器的气相色谱仅检测其血清中有机氯农药（DDTs和HCHs）含量并比较其差异,其结果与年龄及体重指数（BMI）进行相关性分析.结果 乳腺癌患者血清中α-HCH、β-HCH和PP＇-DDE含量高于乳腺良性疾病患者,差异均有统计学意义（P均〈0.05）.2组患者血清中β-HCH、PP＇-DDE含量与年龄及BMI呈正相关（乳腺癌组：r值分别为0.272、0.330和0.207、0.313,P均〈0.01;乳腺良性疾病组：r值分别为0.339、0.260和0.227、0.209,P〈0.01或P〈0.05）.结论 乳腺癌患者血清有机氯农药残留物水平明显高于乳腺良性疾病患者,且含量与年龄及体重指数呈正相关,符合有机氯在高等生物体内的蓄积和排泄特性,为乳腺癌的病因研究和科学预防提供了理论依据.

Objective To evaluate the levels of serum organochlorine pesticide residues in breast cancer patients and benign breast disease patients from Tangshan areas. Methods One hundred fifty-eight breast cancer patients and 129 benign breast disease patients from two districts of TangShan were entrolled in the study. The levels of serum organochlorine pesticides （ DDTs and HCHs） were detected through gas chromatography/electron capture. Spearman＇s rank correlation was used between age, BMI and the level of serum organochlorine pesticide residues in patients. Results The serum levels of a-HCH, p-HCH and PP＇-DDE between breast cancer patients and benign breast disease patients were statistically different（P 〈0. 05）. The serum levels of p-HCH and PP＇-DDE were positively correlated with age and BMI in both groups, with correlation coefficients of 0. 272 and 0. 330 for age and 0. 207 and 0. 313 for BMI in the breast cancer patients,as well as correltion coefficients of 0. 339 and 0. 260 for age and 0. 227 and 0. 209 for BMI in the benign breast disease patients. Conclusions The levels of organochlorine pesticide residues in serum in breast cancer patients were higher than those in benign breast disease patients and were positively correlated with age and BMI. The results offer more information to the pathogenesis, prevention and control measures of breast cancer.