小儿肾小球疾病血清一氧化氮变化的研究

The changes of serum nitric oxide in children with glomerular diseases

采用镉还原和Ｇｒｉｅｓｓ反应法，测定１６例原发性单纯性肾病综合征（ＩＮＳ）、２０例急性肾小球肾炎（ＡＧＮ）和２６例过敏性紫＊（ＨＳＰ）病儿血清中一氧化氮（ＮＯ）的稳定代谢产物ＮＯ２＋ＮＯ３浓度。结果发现三种肾小球疾病病儿血清ＮＯ与５２例健康儿童比较分别有不同程度变化；ＩＮＳ活动期较ＡＧＮ急性期显著增高；ＨＳＰ中有肾损害表现病儿明显高于无肾损害表现病儿．本研究提示，血清ＮＯ水平变化与肾小球疾病的不同病因及病理损伤有关；测定血清ＮＯ可能有助于鉴别ＩＮＳ与ＡＧＮ以及其它炎症性肾小球疾病，可能对判断ＨＳＰ的病情严重程度及指导治疗有一定参考价值。

Using the Griess Reaction the stable metabolite of nitric oxide(No in serum was examined in children withidioapatic nephrotic syndrome(INS), acute glomerulonephritis(ANG) and Henoch - Schonlein purpura(HSP). Theresults showed that the serum NO of patients with INS, AGN and HSP changed in different degress as comparedwith normal control. These fmdings suggested that the level of serum NO was correlated with different illnesscourses of gloinerular diseases and the measurement of serum NO concentration might be an useful method todistinguish INS from AGN and help to judge the pathological severity of HSP.