米非司酮配伍米索前列醇终止10～16周妊娠的临床观察

The clinical observation of terminating 10-16 Weeks' gestation usingmiferistone and misoprostol

本文对７８例１０～１６周孕妇采用米非司酮配伍米索前列醇终止妊娠，方法为一次或分次口服米非司酮１５０ｍｇ．４８小时后首次服米索前列醇０．６ｍｇ，然后视宫缩情况每２～３ｈ服索前列醇０．４ｍｇ．但最大剂量不超过１．８ｍｇ。结果：成功率８８．５％（其中完全流产率６５．２％，不全流产率３４．８％），失败率１１．５％，平均引流产时间７．３±２．２ｈ．阴道出血量≤月经量８６．９％，副反应小。米非司酮一次顿服法与分次服法间、未产妇与经产妇间的成功率和流产时间均无显著性差异（Ｐ＞００５）。结论：米非司酮配伍米索前列醇终止１０～１６周妊娠效果好，副作用少，值得临床推广应用。

This study discussed the method of terminating 10-16 weeks' gestation of 78 women using miferpistone andmisoprostol. Method:First, pregnant women with 10￣16 weeks' gestation well given 150mg miferpistone at onetime or at several times. 48 hours later were given 0.6mg misoprostol. Then according to the labour of uterine, todetermine whether being given 0.4mg misoprostol per 2 hours per 3 hours. But the maximum quantity ofinisoprostol was beyond 1.8mg. Results:The successful rate of abortion was 88.5 % (in which complete abortion was65.2% and incomplete abortion was 34.8%). The failng rate was 11.5%. Aveage time of abortion was 7.3±2.2hours. The amount of vaginal bleeding was less than that of menstruation. Side effects were small. The abortivetime was not significantly different(P>0.05) between parous and nonparous women. Conclusiog: Usingmiferpistone and misoprostol terminating 10￣16 weeks' bestation has better effects and less side - effects is worthwhile being popularized.