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结核清注射剂抗炎及免疫调节作用的实验研究 被引量:1

Experimental Study on Anti-inflammation and Immunoregulation of TBQ Injection
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摘要 目的通过研究中药复方注射剂结核清(TBQ)对小鼠的抗炎及免疫调节作用,为TBQ注射剂的抗结核免疫药理学和临床前研究提供基础研究依据.方法 (1)ICR小鼠随机分组,进行二甲苯致耳廓肿胀实验及毛细血管通透性实验研究,观察TBQ的抗炎效果;(2)建立环磷酰胺(CY)所致免疫功能低下ICR小鼠模型,随机分组,研究TBQ对小鼠迟发型超敏反应(DTH)的影响.结果 (1)与生理盐水对照组比较,TBQ注射剂高剂量组能明显抑制二甲苯所致小鼠耳廓肿胀度(P<0.01)和小鼠腹腔毛细血管通透性的增高;(2)TBQ高剂量组对免疫功能低下模型具有上调作用.结论 TBQ注射剂高剂量具有抗炎作用及上调特异性细胞免疫应答作用. Objective To study the anti-inflammation and mmunoregulation function of TBQ injection on mice,and to provide basic evidence for the pre-clinical study of anti-tuberculosis immunopharmacology.Methods(1)The anti-inflammation effect of TBQ on the ICR mice was evaluated by the swelling of mouse pinnea caused by dimethylbenzene and capillary vessel penetrating experiment;(2)Immunosuppressive ICR mouse model induced by cyclophosphamide was established and the effect of TBQ on the delayed type hypersensitivity (DTH) of the mice was observed.Results(1)Compared with normal saline control group,the high-dose of TBQ obviously inhibited the swelling of mouse pinnea degree of ICR mouse caused by dimethylbenzene(P〈0.01) and as well as increased the penetration of capillary vessel of abdominal cavity;(2)The high-dose of TBQ could up-regulating effect on the immunity of mice with low-immunity.Conclusion TBQ has anti-inflammation effects and can improve cell-mediated immunity.
出处 《昆明医学院学报》 2010年第7期3-5,12,共4页 Journal of Kunming Medical College
基金 云南省教育厅科学研究基金资助项目(02ZY210)
关键词 结核清 抗炎 免疫调节 细胞免疫 ICR小鼠 TBQ Anti-inflammation Immunoregulation Cell-mediated immunity ICR mouse
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参考文献5

  • 1LENAEERTS A M,CHASE S E,CHMIELEWSKI A J,et al.Evaluation of refapentine in long-term treatment refimens for tuberculosis in mice[J].Antimicro Agents Chemother,1999,43(10):2356-2360.
  • 2何国钧,肖和平.抗结核药物的研究进展[J].中华结核和呼吸杂志,2000,23(10):621-625. 被引量:83
  • 3徐叔云,卞如濂,陈修.药理学实验方法[M].第3版.北京:人民卫生出版社,2002:947-953
  • 4WHITTLE B A.The use of changes in capillary permeability in mice distinguish between narcotic and nonnareotic analgesics[J].Brit J Pharmacol,1964,22 (2):246-253.
  • 5CORSINI A C,BELLUCCI S B,COSTA M G.A simple method of evaluating delayed type hypersensitivity in mice[J].J Immunol Methods,1979,30:195-200.

二级参考文献2

  • 1Ji B,Antimicrob Agents Chemother,1998年,42卷,2066页
  • 2何国钧,中华结核和呼吸杂志,1993年,16卷,73页

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