巨噬细胞集落刺激因子与妊高征关系的研究

Relationship Between Macrophage Colong-Stimulatine Factor and Pregnancy Induced Hypertension

采用酶联免疫双抗体夹心（ＥＬＩＳＡ）法测定了２１例妊娠高血压综合征（下称妊高征）患者（妊高征组）、２４例正常晚期妊娠妇女（正常妊娠组）及１０例健康非孕妇女（非孕组）的血浆中巨噬细胞集落刺激因子（Ｍ－ＣＳＦ）浓度。结果：血浆Ｍ－ＣＳＦ浓度正常妊娠组显著高于非孕组（Ｐ＜０．００１），妊高征组显著高于正常妊娠组（Ｐ＜０．０５），重度妊高征患者显著高于轻、中度妊高征患者（Ｐ＜０．０５）和正常妊娠组（Ｐ＜０．０１），轻、中度妊高征患者与正常妊娠组比较无显著差异（Ｐ＞０．０５）。认为妊高征患者Ｍ－ＣＳＦ的产生和作用增加是其胎盘结构和功能改变的基础。

The concentrations of Plasma macrophage colony stimulating factor (M CSF)in 21 patients with pregnancy induce hgpertension (PIH group),24 normal pregnant women(normal pregnant group)and 10 nonpregnant women (nonpregnant group)were measured by enzyme linked immunosorbent assay(ELISA) Results:The concentration(897 27±255 96ng/L) of plasma M CSF in normal pregnant group was higher markedly than that of nonpregnan group(P<0 001),the concentration of plasma M CSF in PIH group was nigher markedly than that of normal pregnant group (P<0 05),the concentration of plasma M CSF in severe PIH patients was higher markedly than that of mild and moderate PIH patients(P<0 05) and the normal pregnant women(P<0 01), the concentrations of plasma M CSF in mild and moderate PIH Patients were no marked difference than that of normal pregnont women (P<0 05) The producement and enhancement of M CSF in PIH patients may contribute to the changes of placental structure and function of the patients