1-酰基-2-芳基-1,2,3,4-四氢-4-喹喏酮及其烯醇硅醚的合成研究

Synthesis of Silyl Enol Ether of 1 Acyl 2 Ary1 1,2,3,4 Tetrahydro 4 quinolones

由２′－氨基查尔酮合成了６个２－芳基－１，２，３，４－四氢－４－喹喏酮，其中４个是新化合物。它们未能直接制成烯醇硅醚。但是它们的Ｎ－酰基衍生物在对甲基苯磺酸催化下，与Ｎ，Ｎ－二甲基三甲硅胺反应顺利地生成相应的四氢喹喏酮的烯醇硅醚，收率９０％～９８％。

Benzene sulfonyl 2 aryl 1,2,3,4 tetrahydro 4 quinolones were treated with N, N Dimethyltrimethylsilylamine (Me 3SiNMe 2),catalyzed by trace amount of TsOH,to give trimethylsilyl enol ethers of the azaflavanones in high yield (90%￣98%).The 1 acetyl analogues could also be converted to their corresponding enol ethers.The structural assignments were based on elemental analysis and spectral data ( 1 H NMR,MS,IR).