摘要
Background Painful physical symptoms （PPS） may present as a component of major depressive disorder （MDD）.Their effect in Chinese patients has not been investigated.This analysis reports the changes in disease severity,treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence （PPS＋） or absence （PPS-）of painful physical symptoms.Methods A subgroup of Chinese patients from a large observational 3-month study of patients from Asian countries and regions of China were classified using the modified Somatic Symptom Inventory （SSI） as PPS＋（mean score≥2） or PPS（mean score 〈2）.Depression severity was assessed with the Clinical Global Impression of Severity （CGI-S） scale and 17-item Hamilton depression rating scale （HAMD17）.Pain severity was measured using a visual analogue scale （VAS）,while the EuroQoL （EQ-5D） assessed patient well-being.Antidepressants were compared with regard to their efficacy.Results Of the 299 Chinese patients enrolled in the study, 105 were classified as PPS＋ （73/105, 70% women）.At baseline, PPS＋ patients reported greater pain severity （VAS, mean （SD）： 49.56 （26.49） vs.16.60 （20.99） for PPS-, P 〈0.01）, were more depressed （HAMD17, mean （SD）： 25.32 （5.47） vs.23.33 （5.24） for PPS-, P=0.002） and had poorer quality of life （EQ-5D Health State, mean （SD）： 38.48 （22.38） vs.49.57 （18.54） for PPS-, P 〈0.001）.PPS＋ patients showed less overall improvement in depressive symptom severity （HAMD17, change from baseline （95% CI）：-17.38（-18.65, -16.12） vs.-19.20 （-20.05,-18.35） for PPS-,P=-0.032; CGI-S, change from baseline （95% CI）： -2.85（-3.11, -2.58） vs.-3.20 （-3.38, -3.02） for PPS-, P=0.044）.Conclusions PPS were less frequent than expected compared with previous studies of Asian populations.PPS＋were associated with greater MDD severity and less improvement than PPS- when antidepressants were given.
Background Painful physical symptoms （PPS） may present as a component of major depressive disorder （MDD）.Their effect in Chinese patients has not been investigated.This analysis reports the changes in disease severity,treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence （PPS＋） or absence （PPS-）of painful physical symptoms.Methods A subgroup of Chinese patients from a large observational 3-month study of patients from Asian countries and regions of China were classified using the modified Somatic Symptom Inventory （SSI） as PPS＋（mean score≥2） or PPS（mean score 〈2）.Depression severity was assessed with the Clinical Global Impression of Severity （CGI-S） scale and 17-item Hamilton depression rating scale （HAMD17）.Pain severity was measured using a visual analogue scale （VAS）,while the EuroQoL （EQ-5D） assessed patient well-being.Antidepressants were compared with regard to their efficacy.Results Of the 299 Chinese patients enrolled in the study, 105 were classified as PPS＋ （73/105, 70% women）.At baseline, PPS＋ patients reported greater pain severity （VAS, mean （SD）： 49.56 （26.49） vs.16.60 （20.99） for PPS-, P 〈0.01）, were more depressed （HAMD17, mean （SD）： 25.32 （5.47） vs.23.33 （5.24） for PPS-, P=0.002） and had poorer quality of life （EQ-5D Health State, mean （SD）： 38.48 （22.38） vs.49.57 （18.54） for PPS-, P 〈0.001）.PPS＋ patients showed less overall improvement in depressive symptom severity （HAMD17, change from baseline （95% CI）：-17.38（-18.65, -16.12） vs.-19.20 （-20.05,-18.35） for PPS-,P=-0.032; CGI-S, change from baseline （95% CI）： -2.85（-3.11, -2.58） vs.-3.20 （-3.38, -3.02） for PPS-, P=0.044）.Conclusions PPS were less frequent than expected compared with previous studies of Asian populations.PPS＋were associated with greater MDD severity and less improvement than PPS- when antidepressants were given.
