紧密连接蛋白CLDN6在卵巢癌、肝癌以及脑膜瘤组织中的表达及意义

Expressions of tight junctions protein CLDN6 in ovarian cancer,liver cancer and meningioma tissues and significances

目的:探讨紧密连接蛋白CLDN6在卵巢癌、肝癌以及脑膜瘤组织中的表达及意义,阐明CLDN6在肿瘤发生、发展中的作用。方法:用免疫组织化学SP法检测36例卵巢癌、30例肝癌以及29例侵袭性脑膜瘤组织中紧密连接蛋CLDN6的表达,同时分别以26例卵巢良性肿瘤,19例癌旁正常肝组织以及29例非侵袭性脑膜瘤组织作为对照,分析CLDN6在上述肿瘤中的表达与临床指标之间的关系。结果:卵巢癌组织中CLDN6表达阳性率为69.44%,卵巢良性瘤中CLDN6表达阳性率为34.62%,两者比较差异具有显著性(P<0.05)。肝癌组织中CLDN6表达阳性率为73.33%,癌旁正常肝组织中CLDN6表达阳性率为26.31%,两者比较差异具有显著性(P<0.05);侵袭性脑膜瘤组织中CLDN6表达阳性率为10.34%,非袭性脑膜瘤组织CLDN6表达阳性率为65.51%,两者比较差异具有显著性(P<0.05)。结论:CLDN6在卵巢癌和肝癌组织中表达上调,在侵袭性脑膜瘤组织中表达下调,推测CLDN6表达改变可能会破坏紧密连接组成成分的比例,进而在肿瘤的发生发展中起一定作用。

Objective To explore the CLDN6 expressions in ovarian cancer,liver cancer and meningioma tissues and clinical significances,and clarify its effects in the occurrence and development of cancer.Methods The expressions of CLDN6 in 36 ovarian cancer tissues,30 liver cancer tissues and 29 invasion meningioma tissues were detected by SP immunohistochemical staining,at the same time,26 benign neoplasm of ovarian tissues,19 normal hepatic tissues and 29 non-invasion meningioma tissues were used as control.Results The positive expression rates of CLDN6 in ovarian cancer tissues and benign neoplasm of ovarian tissues were 69.44% and 34.62%,there was significant difference between them（P〈0.05）;the expression positive rates of CLDN6 in liver cancer tissues and normal hepatic tissues were 73.33% and 26.31%,there was significant difference between then（P〈0.05）;the positive expression rates of CLDN6 in invasion meningioma tissues and non-invasion meningioma tissues were 10.34% and 65.51%,there was also significant difference（P〈0.05）.Conclusion The expression of CLDN6 is up-regulated in ovarian cancer and liver cancer tissues,and down-regulated in invasion meningioma tissues.It may have positive or negative regulatory effect on different cancers by destroying compose of tight junctions.