摘要
目的:比较眼前节相干光断层扫描仪(AC-OCT)与超声角膜测厚仪测量的中央角膜厚度(CCT),评估两种方法的一致性,为AC-OCT临床应用提供客观依据。方法:应用AC-OCT与超声角膜测厚仪测量150名大学生志愿者(300眼)的CCT,对2种方法所得的CCT进行配对t检验及Pearson相关分析,并采用Bland-Alt man plot和Mountain plot进行一致性评价。结果:AC-OCT与超声角膜测厚仪测量CCT的平均值分别为(530.050±33.611)μm和(543.680±35.088)μm,相关分析显示2种方法呈正相关性(r=0.96,P<0.001)。超声角膜测厚仪比AC-OCT测量的CCT厚13.62μm,2种方法测量结果的一致性较差。结论:AC-OCT和超声角膜测厚仪测量的CCT结果存在一定差异,两者之间不能直接替换,但2种测量方法相关性较高,提示可将AC-OCT作为长期观察角膜厚度变化的一种有效方法。
Objective To assess the agreement of central corneal thickness(CCT)measured by anterior chamber-optical coherence tomography(AC-OCT)and ultrasonic pachymeter and provide an objective basis for clinical application of AC-OCT.Methods CCT of 150 college student volunteers(300 eyes)measured by two devices were obtained.The data was analyzed by paired t test and Pearson correlation analysis.Bland-Altman plot and Mountain plot were used to assess the agreement.Results The mean CCT values were(530.05±33.611)μm measured by AC-OCT and(543.68±35.088)μm measured by ultrasonic pachymeter.Regression analysis showed a high correlation between the values obtained by both devices(r=0.960,P〈0.001).Compared with AC-OCT,ultrasonic pachymeter overestimated the CCT by a mean of 13.62 μm.The two modalities had incomparable results.Conclusion It is important to be noted in clinical practice that the measurements acquired by these two modalities are not directly interchangeable.However,the CCT measurements by the AC-OCT and ultrasonic pachymeter are highly correlated.AC-OCT is an effective method to observe the changes of the corneal thickness in the long term.
出处
《吉林大学学报(医学版)》
CAS
CSCD
北大核心
2010年第4期775-778,共4页
Journal of Jilin University:Medicine Edition
基金
国家自然科学基金资助课题(30571992)
吉林大学大学生创新实验计划国家级项目资助课题(2007A75044)
关键词
中央角膜厚度
超声角膜测厚仪
眼前节相干光断层扫描
central corneal thickness
ultrasonic pachymeter
anterior chamber-optical coherence tomography