摘要
【目的】研究环氧化酶-2(cOx-2)在乳腺癌组织中的表达情况与,临床病理指标及预后之间的相关性及与VEGF和HER-2表达的关系。【方法】检测120例乳腺癌石蜡包埋组织中COX-2、HER-2和VEGF的表达。【结果】120例中cox-2的高表达率为38.3%(46/120)。淋巴结转移阳性组和阴性组以及不同临床分期的病人之间COX-2的表达差异有显著意义(P〈0.05),而与病人年龄、肿瘤大小、病理类型、ER、PR等差异无显著意义(P〉0.05)。COX-2在乳腺癌组织中的表达与HER-2/neu、VEGF的表达密切相关(P〈0.01)。COX-2和HER-2共同表达的患者与两者单独表达的患者相比,前者的TNM分期较晚,有显著差异(P=0.027)。COx_2和VEGF共同表达与单独表达的TNM分期无显著差异(P=0.479)。COX-2低表达的患者总生存期较长,与高表达患者的总生存期有显著差异(P〈0.005)。【结论】乳腺癌组织中COX-2的高表达可提示恶性程度高和预后不良。乳腺癌组织中COX-2与HER-2、VEGF的表达相关,且COX-2和HER-2/neu同时高表达时预后更差。
[Objective]To investigate the expression of cyclooxygenase-2(COX-2) in breast cancer and its correlation with clinical pathological parameters, prognosis and the expression of HER-2 and VEGF. [Methods]Paraffin imbedding tissues taken from 120 patients with breast cancer were studied for the detection of COX-2 and HER-2/neu and VEGF expression. [Resultsl The expression of COX-2 in 120 breast cancer was 38.3%. There was significant difference in the expression of COX-2 among positive or negative lymph node metastasis groups and different stages of patients( P〈0. 05). The expression of COX-2 had no significant difference with the patient's age, tumor size, pathological type, ER and PR( P〉0.05). There was close correlation between COX-2 expression and HER-2/neu and VEGF expression in breast cancer tissue( P 〈0.01). Compared with the patients expressing COX-2 or HER-2, the patients co-expressing COX-2 and HER-2 had higher TNM stage, and there was significant difference( P = 0. 479). The patients with low expression of COX-2 had longer total survival time, and had significant difference with patients with high expression of COX-2( P〈0. 005). [Conclusion] The high expression of COX-2 in breast cancer indicates that the malignancy of tumor is high and the prognosis is poor. The COX-2 expression in breast cancer is correlated with HER- 2 and VEGF expression. The high expression of both COX-2 and HER-2 indicates that the prognosis is very poor.
出处
《医学临床研究》
CAS
2010年第7期1292-1294,共3页
Journal of Clinical Research