摘要
目的:为加深对影响鼻咽癌(NPC)预后因素的认识。方法:采用流式细胞仪(FCM)对44例NPC癌细胞核DNA进行检测,发现二倍体肿瘤(DT)10例,近二倍体肿瘤(nDT)17例,非整倍体肿瘤(AT)17例;44例中,颈淋巴结转移35例,经放疗后3年追综观察,鼻咽局部复发和(或)远处转移24例。将不同DNA倍体的NPC、颈淋巴结转移和预后进行相关性分析。结果:NPCDNA倍体与转移之颈淋巴结及其大小无关;nDT和ATNPC放疗后3年局部复发比率高于DTNPC;无颈淋巴结转移NPC,放疗后3年局部复发率与有颈淋巴结转移者无差别(P>005);与无颈淋巴结转移NPC相比,有颈淋巴结转移者放疗后3年更易发生远处转移(P<005)。结论:NPCDNA倍体与鼻咽局部预后关系较为密切,而颈部淋巴结情况则与远处转移与否有关。
Aim: To recognize the prognostic factors in NPC more profoundly.Methods:\ According to nuclear DNA content measured by Flow Cytometry,44 cases of NPC collected were divided into three categories-10 cases with DT,17 cases with nDT,17 cases with AT; of the 44 cases,35 had metastasis of neck lymph node(NLN),and 24 cases had local recurrence and/or distant metastasis in three years after radiotherapy. The correlation between various DNA ploid and metastasis of NLN and prognosis were analysed.Results: There was no significant difference between DNA ploid and metastasis or size of NLN in NPC; local recurrent rate in nDT and AT was higher than that in DT in three years after radiotherapy; there was no significant difference between local recurrent rate in NPC without metastasis of NLN and in NPC with metastasis of NLN in three years after radiotherapy( P >0.05); distant metastasis in NPC with metastasis of NLN occurred were more often than that in NPC without metastasis of NLN in three years after radiotherapy.Conclusions: There is a close correlation between DNA ploid and nasopharyngeal prognosis in NPC. There is a significant correlation between metastasis of NLN before radiotherapy and distant metastasis in three years after radiotherapy in NPC.
出处
《暨南大学学报(自然科学与医学版)》
CAS
CSCD
1999年第2期76-79,83,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家自然科学基金