兔矢状缝扩张过程中环腺苷酸含量的变化

Changes of Endogenous cAMP Level in Interparietal Suture after Expansion

目的：了解兔矢状缝扩张过程中环腺苷酸含量的变化规律。方法：选用兔顶骨矢状缝，用放射免疫法测定骨缝受不同大小，不同时间扩张力后，骨改建相关因子环腺苷酸（ｃＡＭＰ）的含量变化规律。结果：（１）骨缝受扩张力后，内源性ｃＡＭＰ在受力后１ｄ时低于对照水平，以后又上升至高于对照组水平；（２）大力组ｃＡＭＰ含量下降程度比小力组大。结论：较大的力引起的组织损伤大，骨改建延迟。在临床上快速扩大骨缝需更长的保持时间。

Aim: To evaluate endogenous cAMP levels in interparietal sutures after expansion. Methods: Using different magnitude and timing forces to observe the changes of cAMP levels. Results: (1)cAMP level declined after one day of suture expansion, then followed by a raise to higher than control groups. (2) Light force group always has higher cAMP levels than heavy force group. Conclusion: Bone remodeling was delayed and tissue damage was more serious by heavy forces. Thus rapid expansion needs longer retention time than slow expansion.