丁胺卡那保留灌肠治疗婴幼儿腹泻的有效性及安全性探讨

Discussion the Therapeutic Effects Safety of Amikacin Retention-enema in the Treatment of Infant Acute Diarrhea

目的探讨丁胺卡那霉素保留灌肠治疗婴幼儿急性腹泻的疗效、安全性。方法将342例婴幼儿急性腹泻患儿随机分为两组。治疗组180例采用丁胺卡那霉素保留灌肠;对照组162例采用思密达保留灌肠,两组患儿均治疗5d,调节肠道微生态,口服补液,纠正水电解质及酸碱平衡紊乱。随访3个月,无不良反应发生。结果治疗组总有效率97.2%,对照组总有效率72.8%,经统计学处理,有显著性差异(P<0.05)。结论丁胺卡那霉素保留灌肠价廉、高效、安全,值得临床推广。

Objective Discussion of the therapeutic effects and safety of amikacin retention-enema in the treatment of infant acute diarrhea. Methods 324 infant suffering from acute diarrhea were divided into control and experimental groups randomly. 180 cases of experimental group were treated by amikacin retention-enema, while 162 cases of control group by smecta retention-enema, and the treatment of both groups will last for fives days, during which gastrointestinal micro-ecosystem can be modulated, water-electrolyte disturbance can be corrected and acid-base imbalance can be controlled, there exists no side-effect by tracking for three months. Result The total eff iciency ratio was 97.2% in experimental group, 72.8% in control, and there was the signif icant difference between two groups（P0.05）. Conclusion Amikacin retention-enema is effective and safety, which is worthy of clinical expanding.