T淋巴细胞亚群水平对阿德福韦酯治疗慢性乙型肝炎疗效的影响

T- lymphocyte subsets levels on the efficacy of adefovir in the treatment of patients with chronic hepatitis B

目的观察T淋巴细胞亚群变化对阿德福韦酯治疗CHB患者疗效的影响。方法根据治疗前T淋巴细胞亚群水平将42例CHB患者分为CD4+/CD8+细胞比值低水平组和高水平组,观察阿德福韦酯治疗12个月的疗效。结果治疗后两组患者ALT和AST水平下降,但高水平组下降更明显(P<0.05);治疗后两组患者血清HBVDNA水平分别为4.2±1.2copies/ml和4.5±1.5copies/m(lP>0.05);治疗后高水平组患者HBeAg阴转率为38.89%(7/18),低水平组为18.75%(3/16,P<0.05)。结论治疗前T淋巴细胞亚群水平较高的CHB患者在应用阿德福韦酯治疗后疗效较好。

Objective To observe the efficacy of adefovir on patient with CHB. Method 42 CHB patients were divided into two groups based on the ratio of CD4^＋/CD8^＋. Two groups received adefovir for 12 months. Results After 12 months treatment,the high level group got a better improvement in the liver function,HBV DNA loss and HbeAg negative rate. Conclusion Pre-treatment levels of T lymphocyte subgroup in CHB will influence the efficacy of adefovir dipivoxil treatment.