立体定向放射联合肝动脉灌注化疗栓塞治疗原发性肝癌临床分析

Clinical analysis of body gamma knife combined with transcatheter arterial chemoembolization for patients with primary hepatic carcinoma

目的探讨立体定向放射治疗联合经肝动脉化疗栓塞(TACE)治疗原发性肝癌的疗效。方法单纯TACE治疗58例,TACE联合伽玛刀治疗62例肝癌患者,比较治疗后的近期和远期疗效。结果在治疗后3个月,在单纯TACE治疗的58例患者中,总有效率(CR+PR)为60.3%(35/58),在TACE联合伽玛刀治疗组的62例患者中,总有效率(CR+PR)为79.0%(49/62,P<0.01);TACE组治疗后1年、2年和3年生存率分别为67.2%(39/58)、34.5%(20/58)和18.9%(11/58),TACE联合伽玛刀组分别为72.6%(45/62)、41.9%(26/62)和22.6%(14/62)。结论立体定向放射治疗联合TACE治疗原发性肝癌是治疗肝癌安全有效的方法,可以提高患者的生存率。

Objective To evaluate clinical therapeutic effectiveness of stereotactic conformal radiotherapy （body gamma knife）combined with transcatheter arterial chemoembolization （TACE）for primary hepatic carcinoma （PHC）. Methods A total of 120 patients with unresectable PHC were randomly divided into two groups. 58 patients were treated with TACE,while 62 patients with TACE combined with stereotactic conformal radiotherapy. Results There were 7CR,28PR,16NC and 7PD in the group treated with TACE and 10CR,39PR,11NC,2PD in the group treated with TACE combined with stereotactic conformal radiotherapy;The group treated with TACE had a median survival duration of 9.3 months and 12.5 months in the group treated with TACE compared with stereotactic conformal radiotherapy. Conclusion The stereotactic conformal radiotherapy technique combined with transcatheter arterial chemoembolization is a safe and effective treatment for PHC and improve the survival of PHC patients.