更昔洛韦治疗老年带状疱疹48例疗效观察

Efficacy of Ganciclovir for Senile Herpes Zoster

目的观察更昔洛韦治疗老年带状疱疹的临床疗效。方法将96例老年带状疱疹患者随机分为两组,治疗组48例,给予更昔洛韦治疗;对照组48例,给予阿昔洛韦治疗。两组均用药10d后观察临床症状、体征变化,判定治疗效果。结果治疗组在止疱时间、止痛时间、结痂时间明显短于对照组,差异均有统计学意义(P均<0.01),治疗组与对照组治愈率分别为72.92%和56.25%、有效率分别为89.58%和72.91%,两组治愈率和有效率分别比较,差异也均有统计学意义(P均<0.05)。结论更昔洛韦治疗带状疱疹临床疗效明显优于阿昔洛韦。

Objective To observe the clinical efficacy of ganciclovir in the treatment of senile herpes zoster.Methods 96 elderly patients with herpes zoster were randomly divided into 2 groups.Treatment group（48 cases）received ganciclovir treatment,while the control group（48 cases）received acyclovir treatment.The clinical symptoms and signs change were observed after the medication treatment of 10 days,and the therapeutic effect were evaluated.Results There was significant difference between two groups on the time of blister recession,the onset of incrustation and the time of pain alleviation（all P〈0.01）.The cure rates of treatment group and control group were 72.92% and 56.25%,and effective rates were 89.58% and72.91%,respectively.There was statistical difference（P〈0.05）.Conclusion The clinical efficacy of Ganciclovir is superior to acyclovir in treating herpes zoster.