卡托普利对大鼠血管抗氧化作用的研究

Research of Captopr to the rat blood vessel damage protective function

目的:探讨卡托普利对HTL所致大鼠血管内皮功能损伤的保护作用及其机制。方法:选择28只大鼠,实验分为4组,①正常对照组,正常大鼠每天灌胃生理盐水(0.1ml/kg)。②HTL损伤组,将HTL溶解于生理盐水中每天灌胃1次(50mg/kg)。③～④卡托普利低、高剂量治疗组,HTL(50mg/kg)分别与卡托普利(10、40mg/kg)每天灌胃1次;连续灌胃8周,测定血清MDA、SOD。结果:HTL损伤组血管组织SOD的活性明显减弱,MDA的浓度显著增加,与正常对照组比较,差异有统计学意义(P<0.05);经卡托普利(10、40mg/kg)处理后,血管组织中MDA含量降低,SOD活性增强,与HTL损伤组比较,差异有统计学意义(P<0.05)。结论:卡托普利对大鼠血管内皮功能损伤保护作用明确,具有血管抗氧化作用,可以在临床上进一步研究。

Objective：To discuss Captopr to the rat blood vessel bast function damage protective function to HTL and the mechanism.Methods：Chose 28 rats,the experiment were divided into 4 groups,①normal control group,the stomach of normal rats were filled with Physiological Saline（0.1 ml/kg） every day.②HTL damage group,HTL was dissolved in the Physiological Saline filled stomach of the rats（50 mg/kg） one time every day.③ -④ low and high -dose Captopr treatment group,HTL（50 mg/kg） with Captopr（10,40 mg/kg） filled the stomach separately one time every day.Continuously filled the stomach for 8 weeks,detected MDA,SOD in blood serum.Results：In HTL damage group SOD activity of blood vessel organizes were weaken obviously,the MDA density was obviously increased and had significant difference with the normal control group（P0.05）.After Captopr（10,40 mg/kg） was used,MAD density of blood vessel organizes contently were reduced,SOD activity was enhanced,expressing significant difference with the HTL damage group.Conclusion：Captopr to the rat blood vessel function damage protective function is clear and definite,and possesses the blood vessel oxidation resistance function,may further study in clinic.