不同中药复方降糖作用机制研究

Hypoglycemic activity of different compound Chinese medicine

目的:探讨不同中药复方的降糖作用机制。方法:采用一次性腹腔注射STZ造成小鼠糖尿病模型,测定给药前后1h血糖、口服葡萄糖耐量、空腹血糖、血清及肾组织MDA含量和肾组织NO含量。结果:与DM组相比,DM-J、DM-Q、DM-B、DM-CL、DM-CH组血糖分别降低了给药前血糖的26.70%、18.48%、22.08%、22.18%、15.44%。与DM组相比,除DM-J组,其余各组肾组织中NO水平显著降低。各组血清中MDA含量与DM组相比,只有DM-Q和DM-B两组表现出显著性降低。结论:糖尿病早期,给予复方Q、B、J、C均有降低血糖的作用。除J外,各复方都有降低糖尿病早期肾组织NO产生增加的作用,能减轻由NO增加造成的肾脏损伤,但只有Q和B有降低血清MDA含量的作用,减轻脂质过氧化的作用。

Objective：To study the hypoglycemic activity and mechanism of different compound Chinese medicine.Methods：The diabetic modle was established by ip STZ one time.Blood glucose,oral glucose tolerance,fasting blood glucose,the content of NO in kidney,the content of MDA in serum and kidney were assayed.Results：After administration,blood glucose decreased 26.70%,18.48%,22.08%,22.18%,15.44% in DM-J,DM-Q,DM-B,DM-CL and DM-CH group respectively.DM-Q,DM-B,DM-CL and DM-CH group could decrease the content of NO in kidney.Only DM-Q and DM-B group could decrease the content of MDA in serum compared with DM group.Conclusion：Formula Q,B,J,C had hypoglycemic activity.All of the formulas could inhibit the production of NO and the impairment in kidney except formula J.Only Q and B could decrease the content of MDA in serum.