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头孢氨苄胶囊溶出度测定方法的改进

Improvement of the dissolution determining method of Cefalexin Capsules
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摘要 目的:改进头孢氨苄胶囊溶出度的测定方法。方法:采用高效液相色谱法测定,对改进方法的精密度、线性关系、回收率进行了考察,同时将改进方法的测定结果与《中国药典》方法进行了比较。结果:头孢氨苄在12.5~250.0μg/ml浓度范围内,峰面积与浓度呈良好的线性关系(r=1.0000),回收率为99.5%,RSD=0.63%(n=6)。结论:改进后的方法更准确、精密、科学,比《中国药典》方法测得结果更满意。 Objective:To improvement the determining method of dissolution of Cefalexin Capsules.Methods:Dissonlution of Cefalexin was determined by HPLC.The accuracy,precision,linearity and recovery of the improved method were investigated.Then,we compared the results obtained from this improved method and the China Pharmacopoeia method.Results:The linear ranges of cefalexin was at 12.5-250.0(r=1.000 0),and the average recovery was 99.5% with a RSD of 0.63%(n=6).Conclusion:The improved method is more accurate,precise,scientific.The results is more satisfactory than the results of the China Pharmacopoeia method.
出处 《中国医药导报》 CAS 2010年第22期74-75,共2页 China Medical Herald
关键词 头孢氨苄胶囊 溶出度 高效液相色谱法 紫外分光光度法 Cefalexin Capsules Dissolution HPLC UV
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