注射用头孢尼西钠在3种输液中的配伍稳定性研究

Stability of Cefonicid Sodium for Injection in the three kinds of infusion

目的:考察注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液的配伍稳定性。方法:考察配伍后溶液的外观性状,采用HPLC法对配伍后溶液的含量变化进行分析。结果:注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液在6h内配伍稳定,在外观性状和含量上无显著变化;与0.9%氯化钠注射液配伍的稳定性优于其他两种注射液。结论:注射用头孢尼西钠与葡萄糖氯化钠注射液、5%葡萄糖注射液和0.9%氯化钠注射液配伍稳定,为临床使用提供有效的依据。

Objective：To survey the compatible stability of Cefonicid Sodium for Injection in the three kinds of infusion-Glucose and Sodium Chloride Injection,5% Glucose Injection and 0.9% Sodium Chloride Injection.Methods：Cefonicid Sodium for Injection was observed the the outward appearance and measured the content of cefonicid in the compatible solution by HPLC.Results：The compatible stability of Cefonicid Sodium for Injection in the Glucose and Sodium Chloride Injection,5% Glucose Injection and 0.9% Sodium Chloride Injection was stable in 6 h,and there were no obvious changes in outward appearance and content.Conclusion：A determination of the stability of Cefonicid Sodium for Injection can provide a effective basis for clinical application.