舒降之治疗老年人高脂血症的疗效观察

Clinical observation of Zocor in the treatment of elderly patients with hyperlipidemia

目的:观察舒降之(辛伐他汀)20mg每日一次降脂的临床疗效。方法:选35例老年高脂血症患者接受舒降之20mg,每日1次(晚上顿服)治疗,疗程8周。观察治疗前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)。结果:治疗8周后,血清TC、TG、LDL-C较入组前分别降低了29.20%、24.75%、32.87%(均P<0.01),其中,降低TC的总有效率为93.54%、降低TG的总有效率为59.26%。HDL-C较入组前升高了14.12%(P<0.01),升高HDL-C的总有效率为54.54%。结论:舒降之20mg,每日1次服用,安全有效,对改善老年人高脂血症有显著疗效。

Objective：To observe the therapeutic effect and safety of Zocor（Simvastatin） in elderly patients with hyperlipidemia.Methods：35 elderly patients with hyperlipidemia were given Simvastatin 20 mg/d,qn,po,the treatment course was 8 weeks,before and after the treatment,the change of serum TC,TG,LDL-C and HDL-C of two groups were examined and compared.Results：After 8 weeks treatment,serum TC decreased 29.20%,serum TG decreased 24.75%,serum LDL-C decreased 32.87%（all P〈0.01）,serum HDL-C increased 14.12%（P〈0.01）,the total effective rate of serum TC was 93.54%,serum TG was 59.26%,serum HDL-C was 54.54%.Conclusion：Treatment of Zocor 20 mg/d,qn,po,has significant therapeutic effect and safety in elderly patients with hyperlipidemia.