全反式维甲酸联合三氧化二砷治疗急性早幼粒细胞白血病的临床观察

Clinical observalion of the combination of all-trans relinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia

目的观察全反式维甲酸（ATRA）联合三氧化二砷（As2O3）治疗急性早幼粒细胞白血病（APL）的疗效和不良反应。方法ATRA联合As2O3治疗初治APL患者38例。给予全反式维甲酸（ATRA）25mg／（m^2·d），分2～3次口服，三氧化二砷（As2O3）0．16mg／（kg·d）静脉滴注。根据外周血白细胞数量、不良反应等调整用量。结果34例完全缓解（CR），2例死亡。完全缓解（CR）率为89．5％，取得CR所需时间为（24．4±5．2）d。2例出现不良反应均经对症治疗好转。结论ATRA联合As2O3治疗APL疗效好，不良反应少，达CR时间短。

Objective To observe the eficacy and side efect of the all-trans retinoic acid （ATRA） and arsenic trioxide（ As2O3 ）combination in acute promyeloeytic leukemia （APL）. Methods Thirty-eight APL patients were treated with the ATRA and As2O3 combination. ATRA was given 25 mg/m^2 every day and As2O3 was given 0. 16 mg/（ kg · d）. Doses were adjusted according to adverse effects. Results Thirty-four patients achieved complete remission（CR）, the CR rate was 89.5%. The time to achieve CR was （24.4 ± 5.2 ）d. Two patients died due to intracranial hemorrhage. Conclusion The ATRA and As2O3 in the treatment of APL canobtain a higher CR rate and a shorter duration for achieving CR.