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辛伐他汀对早期糖尿病肾病的疗效观察

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摘要 目的探讨辛伐他汀治疗早期糖尿病肾病(DN)疗效。方法选择2007年1月至2009年8月门诊及住院的60例早期糖尿病肾病患者,随机分为治疗组和对照组,对照组给予常规治疗,治疗组每晚加服辛伐他汀20mg,比较两组治疗前及治疗后12周的胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、尿微量白蛋白(MALB)、血肌酐(Cr)、超敏C反应蛋白(hs—CRP)等指标。结果两组治疗后较治疗前尿微量自蛋白(MALB)、Scr和hs—CRP均明显下降(P〈0.05),治疗组尿微量白蛋白(MALB)、Scr和hs—CRP下降比对照组明显(P〈0.05,P〈0.01)。结论辛伐他汀可降低脂蛋白水平及超敏C反应蛋白,减轻尿微量白蛋白,改善肾功能。
出处 《中国临床实用医学》 2010年第8期134-135,共2页 China Clinical Practical Medicine
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  • 1Nakamura T, Ushiyama C, Hirokwa K, et al. Effect of cerivastatin on urinary albumin excretion and plasma endothelin- 1 concentations in type2 diabetes patients with microalbuminuria and dyslipidemia. Am J Nephrol, 2001,21(6) :449 - 454.
  • 2Kim SI, Hah DC,Lee HB. Lovastatin inhibits transforming growth factor-β1 expression in diabetic rat glomeruli and cultured rat mesangial cells. J Am Soc Nephrol,2000,11(1):80-87.
  • 3Ota T, Takamura T, Ando E, et al. Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetdogia, 2003,46 (6): 843 - 851.
  • 4Lee TM, Su SF, Tsai CH. Effect of pravastatin on proteinuria in patients with well- controlled hypertension. Hypertension, 2002,40 ( 1 ): 67 - 73.
  • 5Tesar V. Some important news in clinical nephrology in years 2003 - 2004. Vnitr Lek, 2004,50 (Suppl 1 ): 81 - 87.
  • 6Aika M, Rabikin E, Sugivama S, et al. An HMGCOA reductase inhibitor,cerivas- tatin,suppresses growth of macrophage expressing matrix metalloproteinases, and tissue factor in vivo and in vitro. Circulation, 2001,103:276 - 283.
  • 7Elisaf M, Mikhailidis DP. Statins and renal function. Angiology,2002,53(5) :493 - 502.
  • 8EpsteinM, Campese VM. Pleiotropic effects of 3 - hydroxy-3- methylglutary coenzyme a reductase inhisitors on renal funtion. Am J Kidney Dis, 2005,45 (1): 2 - 14.
  • 9Chong PH,Seeger JD,Franklin C.Clinically relevant differences between the statins:implications for therapeutic.Am J Med,2001,111,390~40
  • 10Kim SI,Han DC,Lee HB.Lovastatin inhibits transforming growth factor-β1 expression in diabetic rat glomeruli and cultured rat mesangial cells.J Am Soc Nephrol,2000,11,80~87

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