中药活血通络法佐治糖尿病周围神经病变52例疗效观察

Effective observation on treating 52 cases of diabetic peripheral neuropathy by TCM activating blood and collaterals

目的：观察中药活血通络法佐治糖尿病周围神经病变（DPN）的疗效及安全性。方法：100例DPN患者按随机数字表法分为两组，两组均在血糖控制稳定后开始观察，对照组52例给予甲钴胺注射液和丁咯地尔注射液静脉滴注，1次／d；观察组48例在对照组治疗基础上采用活血通络法（中药内服兼外敷），2次／d。2组疗程均为30d。观察治疗前后临床症状、体征、运动神经传导速度（MNCV）及感觉神经传导速度（SNCV）等指标的改变。结果：观察组总有效率显著高于对照组（P〈0．05）；观察组的4项神经传导速度均显著高于对照组（P均〈0．05）。两组治疗期间均无严重的不良反应。结论：中药活血通络法佐治糖尿病周围神经病变安全有效，中西医结合治疗有协同作用。

Objective： To observe the effect and security of treating diabetic peripheral neuropathy by TCM activating blood and collaterals （DPN）. Methods： 100 patients with DPN were divided into two groups by random number table, both groups began to observe after the blood sugar had stabilized. Control group （48 cases） received intravenous infusion of Methylcobalamin Injection and Buflomedil injection,one time a day; Observation group （52 cases） were treated with activating blood and collaterals （oral and external application of Chinese Herbs） on the basis of the control group. The treatment course of 2 groups was 30 days. Before and after treatment, clinical symptoms, signs, motor nerve conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV） and other indicators were observed. Results： The total effective rate of the observation group was significantly higher than the control group （P〈0.05）; Four indicators of nerve conduction velocity were significantly higher than the observation group （P〈0.05）. 2 groups were no serious adverse events during treatment. Conclusion： Treating diabetic peripheral neuropathy by TCM activating blood and collaterals is safe and effective, the intergartive medicine has synergistic effect.