原发性肝癌经皮肝动脉化疗栓塞术后疲乏及其影响因素调查

Survey on fatigue and its correlated factors in patients with primary liver cancer receiving transcatheter hepatic arterial chemoembolization

目的探讨原发性肝癌患者经皮肝动脉化疗栓塞(TACE)术后的疲乏及其影响因素。方法采用一般资料调查表、Piper疲乏修正量表、匹兹堡睡眠质量指数量表和抑郁自评量表调查广州地区3所三甲医院113例肝癌患者TACE术后4周左右的社会人口学、疾病治疗、疲乏、抑郁和睡眠质量等资料,并进行统计分析。结果患者疲乏总分为4.24±1.73,疲乏发生率为88.50%,其中中度疲乏占79.65%,重度疲乏占4.42%;其文化程度、年龄及抑郁为疲乏的主要影响因素(P<0.05,P<0.01)。结论疲乏是原发性肝癌患者TACE术后普遍存在的症状,主要受抑郁、文化程度及年龄的影响,应采取有效措施加以应对。

Objective To explore fatigue and its related factors in patients with primary liver cancer receiving transcatheter hepatic arterial chemoembolization（TACE）.Methods General information questionnaire,Piper Fatigue Scale Revise,Pittsburgh Sleep Quality Index and Self-rating Depression Scale were filled out by 113 patients with primary liver cancer receiving TACE after 4 weeks from 3 tertiary hospitals in Guangzhou city.Results The total score of fatigue was 4.24±1.73,with the prevalence being 88.50%;79.65% subjects experienced moderate fatigue and 4.42% had severe fatigue.Educational background,age and depression were the dominant influencing factors（P〈0.05,P〈0.01）.Conclusion Fatigue is a common symptom in patients with primary liver can-cer receiving TACE.It is associated to depression,educational background and age,interventions targeting these factors should be taken.