可控蚀刻荧光二氧化硅纳米颗粒及其载药性质的研究

Controllable etching fluorescent silica nanoparticles and studies for drug-loaded properties

首先采用反相微乳液法制备具有荧光性质的二氧化硅纳米颗粒,在表面覆盖一层聚乙烯吡咯烷酮(PVP)起到保护作用,用NaOH溶液对其进行蚀刻。通过控制蚀刻的时间或改变NaOH溶液的浓度,控制荧光介孔二氧化硅纳米颗粒(FMSN)孔径的大小。利用透射电子显微镜,紫外可见光谱仪,荧光显微镜对FMSN进行表征。结果表明:随着NaOH溶液浓度的增加,蚀刻程度增加;随着蚀刻时间的变长,蚀刻的程度变大。将此结构应用于装载抗癌药物阿霉素(Dox),且对释放进行了研究。

The fluorescent mesoporous silica nanoparticles（FMSN） embedded [Ru（phen）3]Cl2 have been fabricated with reverse microemulsion method. Then The polyvinylpyrrolidone（PVP） molecules were utilized to protect the stability of fluorescent silica nanopaticle（sFSN）. Subsequently,mesoporous fluorescent silica nanoparticle（sMFSN） with different pore size by controlling the etching time and the concentration of NaOH were obtained. TEM,Fluorescence microscope,UV-Vis spectrometer were used to monitor the process,indicating that the mesoporous became bigger with the concentration of NaOH and the etching time increasing. The resulting nanoparticles were applied to load anti-cancer drug Doxorubicin （Dox）. The results showed that the drug could be loaded into FMSN. Additionally,the release of drug from the FMSN was also investigated.