非离子型对比剂碘比醇和碘克沙醇在冠状动脉介入治疗中对患者肾功能影响的观察

Effect of non-ionic contrast medium Iobitridol and Iodixanol on renal function in patients undergoing percutaneous coronary intervention

目的观察非离子型对比剂碘比醇和碘克沙醇在冠脉介入治疗中对肾功能的影响方法 156例因心绞痛行PCI术患者分为两组:其中碘比醇组80例,碘克沙醇组76例,比较两组PCI前后肾功能的变化和对比剂肾病的发生率结果 PCI术后48-72h碘比醇组血清肌酐升高值较碘克沙醇组无明显差异,分别为(3.51+9.9umol/L)和(3.97+6.7umol/LP>0.05),两组对比剂肾病发生率亦无显著性差异,分别为5%和5.26%(P>0.05)结论碘比醇和碘克沙醇在PCI术中对患者肾功能的影响无显著性差异。

Objective To observe the effect of non-ionic contrast medium Iobitridol and Iodixanol on renal function in patients undergoing percutaneous coronary intervention.Methods 156 patients with stable or unstable angina were divided into two groups：Iobitridol was applied to 80 cases（group Ⅰ）,and Iodixanol was applied to 76 cases（group Ⅱ）,The change of renal function,occurrence of contrast-induced nephropathy（CIN） during hospitalization were recorded and compared between the two groups.Results There was significant difference in the increase of serum creatinine between two groups of 48-72 hours after percutaneous coronary intervention,（3.51＋9.9 umol/L） VS（3.97＋6.7umol/L P〉0.05）,neither was in the incidences of CIN between the two groups（5% VS 5.26%,P 〉0.05）,Conclusion The effect on renal function has no significant difference between Iobitridol and Iodixanol during percutaneous coronary intervention.